Dr. Will Bulsiewicz is a gastroenterologist, New York Times bestselling author, and one of the world’s preeminent authorities on gut health. We discuss the gut-immune connection, the four nutritional workhorses, circadian eating, and why healing sometimes has nothing to do with diet. Check out his 2 previous appearances on the podcast:
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00:00:00 Introduction
00:01:27 The Gut-Immune Connection & Chronic Disease
00:05:28 Summary of the Gut-Inflammation Link
00:06:06 Nuance: Genetics and Disease
00:06:56 Innate vs. Adaptive Immunity
00:10:47 The Gut Barrier and Immune Protection
00:12:47 Chronic Low-Grade Inflammation Symptoms
00:14:52 Medical System’s Approach & Testing Limitations
00:16:53 Microbiome Geography & Testing Challenges
00:18:02 Role of the Mucosal Layer
00:18:47 Short Chain Fatty Acids & Gut Health
00:19:40 Self-Diagnosis & Prevalence of Inflammation
00:22:37 The Microbiome as a Life Story
00:23:24 Drivers of Poor Gut Health: Food & Environment
00:24:04 Ultra-Processed Foods & Health Risks
00:26:48 Modern Lifestyle & Loneliness
00:28:31 Sponsor Break
00:31:07 Ultra-Processed Foods: Mechanisms of Harm
00:33:01 Sugar, Salt, and Fat: Microbiome Impact
00:37:59 Hyperpalatability & Overeating
00:40:36 Food Additives & Regulatory Gaps
00:45:42 Personal Agency vs. Systemic Change
00:48:04 Dietary Interventions: Where to Start?
00:52:21 The Four Nutrients: 1. Fiber
00:55:12 Prebiotic Fiber & Resistant Starch
00:57:53 Diversity of Plant Foods
00:59:21 Carnivore Diet & Fiber Debate
01:02:54 Sponsor Break
01:05:59 Short Chain Fatty Acids: Anti-Inflammatory Power
01:09:57 The Four Nutrients: 2. Polyphenols
01:15:35 The Four Nutrients: 3. Omega-3 fats
01:24:52 Seed Oils & Inflammation Debate
01:27:49 The Four Nutrients: 4. Fermented Foods
01:31:06 Recap: The Four Workhorses
01:32:08 Environment, Circadian Rhythm, and Gut Health
01:34:22 Circadian Rhythm & Morning Sunlight
01:42:22 Time-Restricted Eating & Meal Timing
01:47:45 Alcohol & Gut Barrier Disruption
01:52:19 Emotional & Spiritual Health
01:58:41 Sympathetic vs. Parasympathetic Balance
02:03:21 Trauma, Healing, and the Gut
02:09:36 Personal Story: Family, Forgiveness, and Faith
02:24:23 Conclusion: Holistic Health & Final Thoughts
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Thanks To The Team: Jason Camiolo, Dan Drake, Morgan McRae, Blake Curtis, Desmond Loh
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Hi I’m Rich Roll. I’m a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I’m a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
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